Activation of AhR by ITE in DCs induces differential gene expression over time.

To evaluate the effects of AhR activation in dendritic cells (DCs) over time, DCs isolated from human blood or murine spleens were incubated with the AhR ligand ITE for 6 hours, 18 hours, or 72 hours. Treatment with ITE was found to induce transcriptional programs associated with immunoregulatory/ immunosuppressive mchanisms. Dendritic cells isolated from peripheral blood of healthy human donors or from the spleens of healthy B6 mice were incubated with the AhR ligand ITE for 6 hours, 18 hours, or 72 hours.