Unique microglial transcriptomic signature within the hippocampal neurogenic niche

We utilize single cell RNA-sequencing to uncover different myeloid lineage populations in the adult murine hippocampus. By evaluating transcriptome profiles of over 20,000 cells, we have uncovered heterogeneity in innate immune cells of the hippocampus. In particular, we find a transcriptionally distinct population of cells corresponding to microglia in the subgranular zone of the hippocampus, the site of adult neurogenesis. Our results provide a reference for differentially expressed genes that can be used to characterize subpopulations within the hippocampal myeloid population. 3 single cell RNA-sequencing samples of hippocampal myeloid cells originating from 12 biological replicates. Six male and six female samples.