Raw data_Figures and Raw data_Supplementary Figures

Raw data_Figures:
Fig 1B-C, E-G
Fig 2E-H
Fig 3E-G
Fig 4C-E
Fig 5C-D
Fig 6C-G
Fig 7F-I

Raw data_Supplementary Figures:
Fig S1A-D
Fig S2C-E, J-L
Fig S3A-L, Q-S
Fig S4E-G, I
Fig S5A-D, H-K
Fig S6C-D, G-J
Fig S7A-B, D-F

Highlights:
* Both Piezo1 and Piezo2 dramatically enhance the mechanical activation of TREK/TRAAK K2P channels, slow down activation/deactivation and remove inactivation as demonstrated by electrophysiological patch clamp functional recordings
* Piezo1/2 cause a pre-stress of TREK/TRAAK channels attributable to a local depletion of membrane cholesterol (patch clamp)
* A native regulation between endogenous Piezo1 and TREK-1/2 occurs in mouse gingival fibroblasts, acting in concert to delay gum wound healing (patch clamp and in vivo)
* Piezo1 and TREK-1 are in close proximity (not necessarily directly interacting), within the same nanodomain in the plasma membrane (co-immunoprecipitation, proximity assay, co-localization by confocal microscopy)