3D cyto- and receptor architectonic map of macaque superior parietal area TSA (v1.0)

A multimodal analysis of the macaque superior parietal was carried out to create a 3D atlas integrating and reconciling discrepancies between previously published maps. This project involved a quantitative and statistically testable approach to the analysis of cytoarchitecture in the macaque monkey parietal lobe, in combination with an in vitro quantitative receptor autoradiographic analysis of the regional and laminar distribution patterns of 15 different neurotransmitter receptors. The borders of the identified areas were traced onto the macaque stereotaxic space provided by the MEBRAINS and Yerkes 19 templates. We provide here for the first time a map of area TSA of the macaque monkey brain integrating cyto- and receptor architectonic features in stereotaxic space. It constitutes a valuable resource for the analysis of functional experiments with non-human primates, and provides crucial data for modeling approaches with realistic synaptic dynamics

本研究针对猕猴顶上小叶开展多模态分析，旨在构建一套三维图谱，整合并协调已发表图谱间的差异。本项目采用定量且可经统计学检验的分析方法，对猕猴顶叶的细胞构筑进行解析，并结合体外定量受体放射自显影技术，分析15种不同神经递质受体的区域与层状分布模式。研究所识别脑区的边界被标注于由MEBRAINS与Yerkes 19模板提供的猕猴立体定位空间中。本研究首次提供了猕猴大脑TSA脑区的图谱，该图谱整合了立体定位空间下的细胞构筑与受体构筑特征。该图谱可为非人类灵长类动物的功能实验分析提供宝贵的研究资源，同时为基于真实突触动态的建模研究提供关键数据。