Rhodium(II)-Catalyzed Enantioselective C−H Functionalization of Indoles
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https://figshare.com/articles/dataset/Rhodium_II_Catalyzed_Enantioselective_C_H_Functionalization_of_Indoles/2691478
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资源简介：
A catalytic, enantioselective method for the C−H functionalization of indoles by diazo compounds has been achieved. With catalytic amounts of Rh2(S-NTTL)4, the putative Rh−carbene intermediates from α-alkyl-α-diazoesters react with indoles at C(3) to provide α-alkyl-α-indolylacetates in high yield and enantioselectivity. From DFT calculations, a mechanism is proposed that involves a Rh−ylide intermediate with oxocarbenium character.
创建时间：
2011-02-16
