A new Co(II)-bearing coordination polymer: structural characterization and treatment effect on CVB3-induced myocarditis via suppressing inflammatory response

By employment of the mixed-ligand approach, a new Co(II)-based coordination polymer with the chemical formula of [Co(ox)(ditb)] (<b>1</b>, ox = oxalic acid, ditb = 1,4-di(1H-1,2,4-triazol-1-yl)butane) was successfully obtained. Furthermore, a green hand grinding technique has been implemented to reduce the particle size of the complex <b>1</b> to generate nanoscale <b>1</b> (denoted as nano <b>1</b> hereafter) with sheet-like morphology. To evaluate the protective of the nano <b>1</b>, the histopathology evaluation of the CVB3-induced myocarditis animal model was performed. To reveal the relationship between the cell inflammatory response and the compound protective effect, the ELISA was conducted to determine the content of IL-1 and TNF-α in the myocardial tissue.