一种基于醇类气体浓度在线检测的发酵过程反馈补料控制装置及方法

本发明公开了一种基于醇类气体浓度在线检测的发酵过程反馈补料控制装置及方法,依据电化学传感器在线检测发酵生产中的醇类气体浓度,通过控制醇类代谢产物浓度达到发酵过程的反馈控制补料,使醇类浓度以梯度递减形式实现发酵过程中的反馈控制补料,有效且及时的进行补料控制工作,从而保证微生物发酵过程中菌体浓度的稳定,提高微生物发酵产物的质量和产量.依据电化学传感器的在线检测方法进行发酵生产的反馈补料控制,具有控制准确和操作重复性好,能够及时的进行发酵生产的补料控制工作,使发酵过程处于一个良好的进程,克服依据经验进行发酵过程补料的弊端,从而使微生物发酵生产高效率的进行,促进发酵过程优化补料控制的工程化应用水平.

This invention discloses a device and method for fed-batch feedback control in fermentation processes based on online detection of alcohol gas concentrations. It detects alcohol gas concentrations during fermentation production online via electrochemical sensors, and realizes fed-batch feedback control of the fermentation process by regulating the concentration of alcohol-derived metabolites. This approach implements fed-batch feedback control with a gradient-decreasing alcohol concentration profile, enabling efficient and timely fed-batch regulation, thereby ensuring stable cell concentration during microbial fermentation and improving the quality and yield of microbial fermentation products. The fed-batch feedback control for fermentation production based on the electrochemical sensor online detection method boasts accurate control and excellent operational repeatability. It allows timely fed-batch regulation of fermentation production, maintaining the fermentation process in a favorable state, overcoming the shortcomings of empirical fed-batch control in fermentation processes, realizing high-efficiency microbial fermentation production, and promoting the engineering application level of optimized fed-batch control for fermentation processes.