RNA-seq in LNCaP cell line overexpressing WT or mutant FOXA1
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https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE133384
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Our data suggested that FKHD-MSs impair the chromatin binding of FOXA1 to AR-dependent enhancers and thus suppress AR transcriptional activity, and promote PCa progression through increasing FOXA1 binding to a subset of AR-independent enhancers that regulates transcription of genes mediating EMT and metastasis We generated LNCaP stable cells with tetracycline-inducible expression of V5-tagged FKHD-MSs or WT FOXA1. RNA-seq experiments were performed on these cell lines with or without DHT
创建时间：
2019-10-15
