Genetic variants from a single patient at different treatment time points.

Each biopsy was at a different anatomic site. Red denotes suspected driver variants; gray denotes variants of unknown significance. Letter preceding tumor location indicates primary (P) or metastatic (M) site. Number in parentheses indicates inferred allelic fraction for mutation calls, or inferred copy number for amplification or deletion calls. See S2 Table for additional details. Note that this patient was treated with crizotinib following the 5th relapse.