Direct C−H Arylation of (Hetero)arenes with Aryl Iodides via Rhodium Catalysis

A new method for the catalytic C−H arylation of heteroarenes and arenes that manifests high activity paired with reasonably broad scope was developed. Under the catalytic influence of RhCl(CO){P[OCH(CF3)2]3}2 and Ag2CO3, the direct C−H arylation of heteroarenes/arenes with aryl/heteroaryl iodides took place to afford a range of biaryls in good to excellent yields with high regioselectivity. Thiophenes, furans, pyrroles, indoles, and alkoxybenzenes are applicable in this arylation protocol.

一种新型催化C-H芳基化方法应运而生，该方法展现出极高的活性，并具备相当广泛的适用范围。在RhCl(CO){P[OCH(CF3)2]3}2与Ag2CO3的催化作用下，异芳烃/芳烃与芳基/杂芳基碘化物实现了直接C-H芳基化反应，从而以良好的至优异的产率和高区域选择性获得了多种双芳烃。在本芳基化协议中，噻吩、呋喃、吡咯、吲哚和烷氧基苯均适用。