3D cyto- and receptor architectonic map of macaque prefrontal area 9m (v1.0)

A multimodal analysis of the macaque prefrontal cortex was carried out to create a 3D atlas integrating and reconciling discrepancies between previously published maps. This project involved a quantitative and statistically testable approach to the analysis of cytoarchitecture in the macaque monkey frontal lobe, in combination with an in vitro quantitative receptor autoradiographic analysis of the regional and laminar distribution patterns of 14 different neurotransmitter receptors. The borders of the identified areas were traced onto a reference macaque monkey brain in stereotaxic space. We provide here for the first time a map of prefrontal area 9m of the macaque monkey brain integrating cyto- and receptor architectonic features in stereotaxic space. It constitutes a valuable resource for the analysis of functional experiments with non-human primates and provides crucial data for modeling approaches with realistic synaptic dynamics.

本研究针对猕猴前额叶皮层开展多模态分析，旨在构建一套整合既往已发表图谱并调和其间差异的三维图谱集。本项目采用定量且可经统计学检验的分析方法，对猕猴额叶的细胞构筑学（cytoarchitecture）特征展开研究，并结合体外定量受体放射自显影（receptor autoradiographic）分析技术，解析了14种不同神经递质受体（neurotransmitter receptors）的脑区分布与层状分布模式。研究人员将所识别脑区的边界标注至立体定位空间（stereotaxic space）中的猕猴标准脑模板上。本研究首次提供了整合细胞构筑与受体构筑特征的立体定位空间下猕猴大脑前额叶9m区（prefrontal area 9m）图谱。该图谱可为非人类灵长类动物（non-human primates）的功能实验分析提供宝贵资源，同时也为基于真实突触动力学（synaptic dynamics）的建模研究提供关键数据。