Supplementary Material for: Burden of Disease and Cost of Illness of Inflammatory Bowel Diseases in Portugal

<b><i>Background:</i></b> Inflammatory bowel diseases’ (IBD) increasing incidence and prevalence place a heavy health and economic burden on society. <b><i>Objectives:</i></b> This study assesses the burden and cost of IBD in Portugal to support the definition of health policies, resource allocation, and patient care. <b><i>Methods:</i></b> The burden of disease was expressed using disability-adjusted life years (DALY). Costs were estimated considering the societal perspective, using a prevalence-based model and prices established by law. An expert panel composed of 5 expert Portuguese gastroenterologists and a patient-reported study were conducted to support the cost analysis and fill in information gaps. <b><i>Results:</i></b> In Portugal, with a prevalence of 24,069 IBD patients and an incidence of 15/100,000, the burden of disease was estimated at 6,067 DALYs: 507 resulting from premature deaths and 5,560 from disability. Total cost was estimated at EUR 146 million per year, with direct costs representing 59%. Average yearly cost per IBD patient is EUR 6,075, where 60% is related to Crohn’s disease and 40% to ulcerative colitis (UC). <b><i>Conclusion:</i></b> This study estimates the annual health burden and cost of IBD in Portugal, thus generating information with the intent to raise awareness of the need to advance health policies as well as better clinical and economic decisions in this pathology.

<b><i>背景：</i></b> 炎症性肠病（Inflammatory Bowel Diseases，IBD）的发病率与患病率持续上升，给社会造成了沉重的健康与经济负担。
<b><i>目的：</i></b> 本研究旨在评估葡萄牙炎症性肠病的疾病负担与医疗成本，为卫生政策制定、资源配置及患者诊疗工作提供科学依据。
<b><i>方法：</i></b> 本研究以伤残调整生命年（Disability-Adjusted Life Years，DALY）作为疾病负担的衡量指标。成本估算采用社会视角，基于患病率模型及法定定价标准开展。此外，本研究组建了由5名葡萄牙资深胃肠病学家组成的专家小组，并开展了患者报告研究，以辅助成本分析并填补相关信息空白。
<b><i>结果：</i></b> 葡萄牙现有炎症性肠病患者24069例，发病率为15/10万，经估算疾病总负担达6067个伤残调整生命年（DALY），其中507个源于过早死亡，5560个源于伤残。年度总成本估算为1.46亿欧元，直接成本占比59%。每位炎症性肠病患者的年均医疗成本为6075欧元，其中60%与克罗恩病相关，40%与溃疡性结肠炎（Ulcerative Colitis，UC）相关。
<b><i>结论：</i></b> 本研究估算了葡萄牙炎症性肠病的年度健康负担与医疗成本，旨在通过生成相关研究数据，提升各界对完善卫生政策、优化该疾病临床与经济决策必要性的认知。