Whole Genome Association Study of Bipolar Disorder

The goal of the project is to identify genes that make individuals more susceptible to bipolar disorder (manic depressive illness) and to better understand the brain pathways involved in the disease. Dataset versioning Version 1: European-American (EA) ancestry only Version 2: Version 1 plus African-American (AA) ancestry Version 3: EA and AA samples plus updated diagnostic criteria Consent groups and participant set General research use (GRU): 1767 controls (1081 EA controls, 686 AA controls) This consent group includes all controls for the Bipolar study, which are a subset of controls for the Schizophrenia study (subset of Schizophrenia: GRU). Bipolar and related disorders (BARD): 841 cases (691 EA cases, 150 AA cases) This consent group includes a subset of the Bipolar cases. Bipolar disorder only (BDO): 653 cases (388 EA cases, 265 AA cases) This consent group includes a subset of the Bipolar cases. ]]>
DIGS DescriptionDIAGNOSTIC Summary SheetDIAGNOSTIC INTERVIEW FOR GENETIC STUDIES (DIGS) 2.0NIMH BIPOLAR DISORDER GENETICS INITIATIVE DATAFILE DOCUMENTATIONDIAGNOSTIC INTERVIEW FOR GENETIC STUDIES (DIGS) 3.0DIAGNOSTIC INTERVIEW FOR GENETIC STUDIES REFERENCE MANUALDiagnosis Form (DIGS4)DIAGNOSTIC INTERVIEW FOR GENETIC STUDIES (DIGS) 4.0Diagnostic Summary SheetControls: Clinical ProceduresControls Questionnaire Administered On-Line by Knowledge Networks (KN)A. DEMOGRAPHICSB. MEDICAL HISTORYC. MODIFIED MINI-MENTAL STATUS EXAMINATIOND. SOMATIZATIONE. OVERVIEW OF PSYCHIATRIC DISTURBANCEF. MAJOR DEPRESSIONG. MANIA/HYPOMANIAH. DYSTHYMIA/DEPRESSIVE/HYPERTHYMIC PERSONALITYI. ALCOHOL ABUSE AND DEPENDENCEJ. DRUG ABUSE AND DEPENDENCEK. PSYCHOSISL. SCHIZOTYPAL PERSONALITY FEATURESM. MODIFIED STRUCTURED INTERVIEW FOR SCHIZOTYPYN. COMORBIDITY ASSESSMENTO. SUICIDAL BEHAVIORP. ANXIETY DISORDERSQ. EATING DISORDERSR. PATHOLOGICAL GAMBLINGS. ANTISOCIAL PERSONALITYT. GLOBAL ASSESSMENT SCALE (GAS)U. SCALE FOR THE ASSESSMENT OF NEGATIVE SYMPTOMS (SANS)V. SCALE FOR THE ASSESSMENT OF POSITIVE SYMPTOMS (SAPS)W. MODIFIED SIS RATINGSX. INTERVIEWER'S RELIABILITY ASSESSMENT Y. NARRATIVE SUMMARYZ. MEDICAL RECORDS INFORMATIONAPPENDIXA. DEMOGRAPHICSB. MEDICAL HISTORYC1. MODIFIED MINI-MENTAL STATUS EXAMINATIONC2. TELEPHONE INTERVIEW FOR COGNITIVE STATUSD. SOMATIZATIONE. OVERVIEW OF PSYCHIATRIC DISTURBANCEF. MAJOR DEPRESSIONG. MANIA/HYPOMANIAH. DYSTHYMIA/CYCLOTHYMIAI. ALCOHOL ABUSE AND DEPENDENCEJ. TOBACCO, MARIJUANA AND OTHER DRUG ABUSEK. PSYCHOSISL. SCHIZOTYPAL PERSONALITY FEATURESM. MODIFIED SISN. COMORBIDITY ASSESSMENTO. SUICIDAL BEHAVIORP. ANXIETY DISORDERSQ. EATING DISORDERSR. PATHOLOGICAL GAMBLINGS. ANTISOCIAL PERSONALITYT. GLOBAL ASSESSMENT SCALE (GAS)U. SANSV. SAPSW. MODIFIED SIS RATINGSX. INTERVIEWER'S RELIABILITY ASSESSMENT, Y. NARRATIVE SUMMARYZ. MEDICAL RECORDS INFORMATIONAPPENDIXA. DEMOGRAPHICSB. MEDICAL HISTORYC1. MODIFIED MINI-MENTAL STATUS EXAMINATIONC2. TELEPHONE INTERVIEW FOR COGNITIVE STATUSD. SOMATIZATIONE. OVERVIEW OF PSYCHIATRIC DISTURBANCEF. MAJOR DEPRESSIONG. MANIA/HYPOMANIAH. DYSTHYMIA/CYCLOTHYMIAI. ALCOHOL ABUSE AND DEPENDENCEJ. TOBACCO, MARIJUANA, AND OTHER DRUG ABUSE AND DEPENDENCEK. PSYCHOSISN. COMORBIDITY ASSESSMENTO. SUICIDAL BEHAVIORP. ANXIETY DISORDERSQ. EATING DISORDERSR. PATHOLOGICAL GAMBLINGS. ANTISOCIAL PERSONALITYT. GLOBAL ASSESSMENT SCALE (GAS)U. SANSV. SAPSX. INTERVIEWER'S RELIABILITY ASSESSMENT, Y. NARRATIVE SUMMARY, Z. MEDICAL RECORDS INFORMATIONAPPENDIXAuthorized access to GAIN Project Datasets: Application Instructions (retired document)Authorized access to GAIN Project Datasets: Application Instructionspre-computed by NCBI .
]]>-8 for a single plate and/or 10-4 for two plates; 6) less than 2 discrepancies between SNP calls on duplicated samples. These thresholds resulted in 362 cases, 671 controls genotyped over 845814 SNPs used in the association analysis. Genome-wide association scan has been pre-computed by NCBI .
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