Differential transcriptome analysis of Dunaliella salina during flagellar assembly. Dunaliella salina

Eukaryotic flagellum is highly conserved in basic structure and biogenesis and defects in ciliary assembly or function lead to a wide range of human disease symptoms. The alga Dunaliella salina (D.salina) provides an excellent model for investigating flagellar/ciliary system However the genomes it carries is unpublished. In this study, using high-throughput illumina RNA sequencing, the transcriptomes from flagella-assembling D. salina were analyzed firstly at an unprecedented depth. Furthermore, the differentially expressed unigenes involved in different signaling pathways of D. salina flagella assembly and human diseases were screened respectively. These pathway- based results not only provide a further understanding to specific processes of ciliogenesis and ciliopathies , but also offer a cue to mechanism of human diseases.