Randomised controlled trial dataset: efficacy of night casting to increase dorsiflexion range in children and young adults with Charcot-Marie-Tooth disease

This dataset is an output of a randomised controlled trial investigating the efficacy of night casting and stretching as a means to increase dorsiflexion range in children and young adults with Charcot-Marie-Tooth disease.
The research design included a randomised trial with concealed allocation, assessor blinding, and intention-to-treat analysis. 30 children and young adults with Charcot-Marie-Tooth disease and restricted ankle dorsiflexion range participated in the trial.  The experimental group received an intervention of 4 weeks of serial night casting followed by 4 weeks of weightbearing stretches. Removable plaster casts were worn for 8 hours every night for 4 weeks. Night casting was followed by a daily stretching program, conducted at home for a further 4 weeks.  The control group received no intervention.
Data was collected on ankle dorsiflexion range, foot deformity, mobility, balance, walking speed, stair climbing speed, number of falls, and other self-reported activity limitations. Outcomes were measured at baseline, 4, and 8 weeks. Data was recorded and stored in spreadsheet (excel) format.
By 4 weeks, serial night casting had increased ankle dorsiflexion range by a mean of 4 deg (95% CI 2 to 6) more in the experimental group than the control group. After a further 4 weeks of weightbearing stretches, the experimental group still had a mean of 3 deg (95% CI 0 to 5) more ankle dorsiflexion range than the control group. Other than reduced time to walk 10 metres at self-selected pace favouring night casting at 4 weeks, outcomes did not differ between groups at any time point. Two minor adverse events were reported in the experimental group. 4 weeks of serial night casting increased ankle dorsiflexion range compared with no intervention, but at 8 weeks there was no significant difference between groups.
This description was drawn from the abstract of the associated publication. For further information and access to the dataset, refer to the associated publication below.

本数据集源自一项随机对照试验的研究产出，该试验旨在探究夜间支具固定与拉伸疗法用于改善夏科-马里-图思病（Charcot-Marie-Tooth disease）患儿及青年患者踝背屈活动度的临床疗效。
本研究采用随机对照设计，包含隐蔽分配、评估者盲法及意向治疗分析。共计30名确诊夏科-马里-图思病且踝背屈活动度受限的儿童与青年受试者参与本次试验。实验组接受为期4周的连续性夜间支具固定，随后再开展4周的负重拉伸干预：可拆卸石膏支具需于每晚佩戴8小时，持续4周；夜间固定阶段结束后，受试者需在家中每日完成拉伸训练，该阶段共计4周。对照组则未接受任何干预措施。
研究收集了踝背屈活动度、足部畸形、活动能力、平衡能力、步行速度、爬楼速度、跌倒次数及其他自我报告的活动受限情况等多项数据。分别于基线期、第4周及第8周进行结局指标测量。所有数据以电子表格（Excel）格式记录并存储。
至第4周时，实验组踝背屈活动度较对照组平均提升4度（95%置信区间：2至6）。在后续4周的负重拉伸干预结束后，即第8周时，实验组踝背屈活动度仍较对照组平均高出3度（95%置信区间：0至5）。除第4周时，实验组在自主选择步速下步行10米的耗时更短，呈现出有利于夜间支具固定干预的结果外，其余各时间点的结局指标两组间均无显著差异。实验组共报告2起轻微不良事件。为期4周的连续性夜间支具固定可较无干预措施提升踝背屈活动度，但至第8周时，两组间已无统计学显著差异。
本数据集描述源自相关学术出版物的摘要。如需获取更多信息或访问该数据集，请参阅下述相关出版物。