Virulence factors enriched among ocular and non-ocular strains, controlling for both MRSA/MSSA status and geography of strain origin.

NIAID Data Ecosystem2026-03-12 收录

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https://figshare.com/articles/dataset/Virulence_factors_enriched_among_ocular_and_non-ocular_strains_controlling_for_both_MRSA_MSSA_status_and_geography_of_strain_origin_/14530312 数据链接链接失效反馈

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Virulence factors enriched among ocular and non-ocular strains, controlling for both MRSA/MSSA status and geography of strain origin.

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2021-05-03

Ciprofloxacin-resistant Staphylococcus aureus keeps resistance and virulence in Iron-restricted Condition

细菌耐药性机制

金黄色葡萄球菌毒力

In summary, this study shows advantages of the CIP-R in the survival, drug resistance and virulence in iron restricted condition. DIA-based proteomics study combined with biochemical validation showed

NIAID Data Ecosystem80

S. aureus gene expression of WT (USA300) vs fakAKO. Staphylococcus aureus

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S. aureus response to fakA deletion Gene expression profiles were generated by microarray analysis of S. aureus WT (USA300) or fakAKO Overall design: S. aureus was grown in LB to an OD600nm of 0.45, a

NIAID Data Ecosystem40

Data of the paper.pdf

细菌耐药性机制

金黄色葡萄球菌毒力

Glutamate metabolism plays a pivotal role in linking the tricarboxylic acid cycle, arginine biosynthesis, and purine metabolism and these pathways have been shown to be involved in persister formation

Figshare2024-06-13 更新10

Crystal structure of Rot, a global regulator of virulence genes in Staphylococcus aureus

金黄色葡萄球菌毒力

蛋白质晶体结构解析

Crystal structure of Rot, a global regulator of virulence genes in Staphylococcus aureus Descriptor: GLYCEROL, HTH-type transcriptional regulator rot Authors: Zhu, Y, Fan, X, Li, X, Teng, M. Deposit d

Protein Data Bank Japan2024-03-20 更新50

This study describes the target receptor and mechanism of action of Staphylococcal superantigen like 13 (SSL13), a secret protein reside on S.aureus immune evasion cluster 2(IEC-2) that previously supposed to modulate immune evasion. In sharp contrast to the characterized SSLs located on the staphylococcal pathogenicity island 2 (SPI-2) , that inhibit immune functions, We demonstrate SSL13 is a chemoattractant and a neutrophil activator that acts via the FPR2. Therefore, SSL13 is a unique SSL member not belonging to the immune evasion class, but is a pathogen alarming molecule sensed by the FPR2. Our study provides a new conception of SSLs, that not only inhibit host immune processes but also recruit human neutrophils to the site of infection, where S. aureus can be disarmed by secreted immune evasion proteins and used as vesicles to other parts of the host. This allow us to better understand of S. aureus pathological processes.

金黄色葡萄球菌毒力

中性粒细胞免疫

Staphylococcal Superantigen-Like (SSL) proteins, one of major virulence factor families produced by Staphylococcus aureus, were previously demonstrated to be immune evasion molecules that interfere wi

NIAID Data Ecosystem30

Virulence factors enriched among ocular and non-ocular strains, controlling for both MRSA/MSSA status and geography of strain origin.

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