LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production

Leucine-rich repeat flightless-interacting protein 1 (LRRFIP1) can bind exogenous double-stranded RNA and double-stranded DNA (Wilson SA et al. 1998; Yang P et al. 2010). LRRFIP1 was shown to mediate Listeria monocytogenes- and vesicular stomatitis virus (VSV)-induced IFN-beta production in mouse primary macrophages by regulating beta-catenin activity. Beta-catenin possibly functions as a transcriptional cofactor of IRF3 to initiate Ifnb1 transcription (Yang P et al. 2010).

富含亮氨酸重复序列的无翼蛋白相互作用蛋白1 (LRRFIP1) 可与外源性双链RNA和双链DNA结合（Wilson SA 等人，1998；Yang P 等人，2010）。研究表明，LRRFIP1可通过调节β-连环蛋白活性，介导小鼠原代巨噬细胞中李斯特菌单核细胞增生李斯特菌和副黏病毒（VSV）诱导的IFN-β产生。β-连环蛋白可能作为IRF3的转录辅助因子，启动Ifnb1的转录（Yang P 等人，2010）。