Smoking Gun - 16492
收藏NIAID Data Ecosystem2026-05-02 收录
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http://flowrepository.org/id/FR-FCM-Z8XZ
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资源简介：
Smoking has been associated with an increased risk of developing rheumatoid arthritis (RA) in individuals carrying shared epitope (SE) HLA-DRB1 alleles. Yet, little is known about the regional and systemic T cell dynamics of smoking and a potential link to T cell infiltration in inflamed synovia. In this study, we, therefore, sought to study T cell features in lung and inflamed joints in smoking versus non-smoking patients.
Conclusion:
The data indicate a profound interplay between a strong MHC predisposition, smoking and induction of autoimmunity by shaping the TCR repertoire.
创建时间：
2024-12-01
