Additional file 2 of Disentangling the divergent causal pathways underlying the association between body mass index and bone mineral density: a comprehensive Mendelian randomization study

Additional file 2: Tables S1–S26: Table S1 Details of GWAS summary data. Table S2 Characteristics of instrumental variables selected for BMI. Table S3 Cochran’s Q for the genetically predicted effects of BMI on eBMD. Table S4 Characteristics of index SNPs in each cluster obtained from MR-Clust analysis. Table S5 Causal estimates of univariable MR analysis of BMI on eBMD using IVs in substantive clusters obtained from MR-Clust. Table S6 Biological pathways for SNPs in clusters with different effects identified by MR-Clust. Table S7 Characteristics of index SNPs identified by colocalization analysis incorporated into the skeletal muscle-tissue instrumented BMI. Table S8 Characteristics of index SNPs identified by colocalization analysis incorporated into the visceral adipose-tissue instrumented BMI. Table S9 Characteristics of index SNPs identified by colocalization analysis incorporated into the subcutaneous adipose-tissue instrumented BMI. Table S10 The average effect sizes of tissue-partitioned instruments. Table S11 Conditional F-statistics for tissue-specific instrumented BMI in multivariable MR analysis. Table S12 Results of tissue-partitioned MR using IVs obtained from a more relaxed threshold of PPA4 > 0.7. Table S13 Characteristics of index SNPs associated with LM or FM in multivariable MR analysis. Table S14 Characteristics of index SNPs associated with LM or BFP in multivariable MR analysis. Table S15 Characteristics of index SNPs associated with LM or BMI in multivariable MR analysis. Table S16 Characteristics of index SNPs associated with LM or BW in multivariable MR analysis. Table S17 Conditional F-statistics for IVs of body composition phenotypes in multivariable MR analysis. Table S18 Causal estimates of univariable and multivariable MR analysis of body composition phenotypes other than LM on eBMD. Table S19 Characteristics of instrumental variables selected for BMI with effect sizes from BMI-GWAS 2015. Table S20 Sensitivity analysis of univariable Mendelian randomization analysis conducted for BMI and eBMD. Table S21 Characteristics of index SNPs in each cluster obtained from MR-Clust analysis with effect sizes from BMI-GWAS 2015. Table S22 Sensitivity analysis of the effect of genetically predicted BMI on eBMD using IVs in substantive clusters obtained by MR-Clust. Table S23 Characteristics of index SNPs identified by colocalization analysis incorporated into the skeletal muscle-tissue instrumented BMI with effect sizes from BMI-GWAS 2015. Table S24 Characteristics of index SNPs identified by colocalization analysis incorporated into the visceral adipose-tissue instrumented BMI with effect sizes from BMI-GWAS 2015. Table S25 Characteristics of index SNPs identified by colocalization analysis incorporated into the subcutaneous adipose-tissue instrumented BMI with effect sizes from BMI-GWAS 2015. Table S26 Sensitivity analysis of tissue-partitioned MR conducted for BMI and eBMD.