Comparative analysis of gene expression in TGF-ß3 mutant mice with cleft palate
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https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE109838
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资源简介：
Comparison of global palatal transcriptomes between wild‐type (WT) and TGF‐β3 ‐/‐ homozygous (HM) mouse embryos at crucial palatogenesis stages, E14.5 when initial contact is reached between palatal shelves and E16.5 when palatal fusion in completed in mice using RNA sequencing technology (RNA-Seq). Our RNA-Seq data revealed that 4115 and 5304 genes were statistically deferentially (p < 0.05) expressed at E14.5 vs E16.5 in WT palates and HM palates, respectively. We then applied a 2.0-fold change cut-off to emphasize on significantly deferentially expressed genes. Genes that were uniquely up/down–regulated in either WT or HM at E16.5 vs E14.5 were identified and considered CP-related genes. Palatal mRNA profiles of wild type (WT) and TGFβ3-/- mice at E14.5 and E16.5 were generated by deep sequencing, in triplicate, using Illumina HiSeq2000
创建时间：
2020-10-02
