Decipher aging related skin microbiome and metabolites crosstalk from a chronologically matched cohort

This study explores how the skin microbiome influences metabolic pathways associated with differences in skin aging among individuals of the same chronological age. By analyzing a cohort of 103 women aged 39-41, we identified key relationships between skin microbial diversity, metabolic functions, and aging phenotypes. Our findings suggest that beneficial bacteria may enhance skin health by promoting antioxidant defenses and regulating pigment metabolism, while harmful microbial shifts may increase susceptibility to skin aging. This study highlights the dynamic interaction between skin microbiota and the host, offering valuable insights into the development of microbiome-targeted anti-aging strategies.