Minimal dataset for the manuscript "Better together against genetic heterogeneity: a sex-combined joint main and interaction analysis of 290 quantitative traits in the UK Biobank".

Dataset "lin2024-sex_combined_interaction-association_signifincant_in_one_or_more_tests-summary.txt" is a minimal dataset to reproduce the figures and tables in the manuscript "Better together against genetic heterogeneity: a sex-combined joint main and interaction analysis of 290 quantitative traits in the UK Biobank". To generate this dataset, see "https://github.com/BoxiLin/t2meta" Steps 0, 1. This dataset is the input for Steps 2, 3, 4, 5 to generate Figures 1-3 and Table 2-3. ##### Column information ######################## The following columns are annotations on each variant in the GWAS, calculated across the analysis subset of 361,194 samples by the Neale lab: code: Phenotype identifier in the form of "[UKB Data field]_raw"variant: Unique variant identifier in the form "chr:pos:ref:alt", where "ref" is aligned to the forward strand.chr: Chromosome of the variant.pos: Position of the variant in GRCh37 coordinates.rsid: rs IDref: Reference allele on the forward strand.alt: Alternate allele (not necessarily minor allele).p_hwe: Hardy-Weinberg p-value.info: Imputation INFO score as provided by UK Biobank. The following columns are sex-stratified test statistics calculated by the Neale lab: minor_allele.x: Minor allele (AF < 0.5) in the female GWAS minor_AF.x: Minor allele frequency in the female GWAS beta.x: Estimated effect size of alt allele in the female GWAS se.x: Estimated standard error of beta in the female GWAStstat.x: t-statistic of beta estimate (= beta/se) in the female GWAS pval.x: p-value of beta significance test in the female GWAS minor_allele.y: Minor allele (AF < 0.5) in the male GWAS minor_AF.y: Minor allele frequency in the male GWAS beta.y: Estimated effect size of alt allele in the male GWAS se.y: Estimated standard error of beta in the male GWAS tstat.y: t-statistic of beta estimate (= beta/se) in the male GWAS pval.y: p-value of beta significance test in the male GWAS The following columns are sex-combined test statistics calculated in our analysis: T.I: test statsitic for interaction effect-only p.T.I: p-value of the interaction effect-only test TSG.L: test statsitic for inverse variance weighted meta-analysisp.TSG.L: p-value of the inverse variance weighted meta-analysisTSG.Q: test statsitic for the omnibus meta-analysisp.TSG.Q: p-value for the omnibus meta-analysis