Identification of the gene(s) responsible for ocular abnormalities of Hirosaki Small Eye Rat (HiSER)

HiSER, established in our laboratory, exhibits ocular abnormalities including opacity, lens involution, and retinal detachment. To identify a causative gene(s) of the HiSER phenotype, microarray analysis was performed between HiSER and normal (SDR) eyes. Total RNA was extracted from HiSER and normal (SDR) eyes, and subjected to microarray analysis.