Crystal structure of S39D HDAC8 in complex with a largazole analogue.
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Crystal structure of S39D HDAC8 in complex with a largazole analogue. Descriptor: (5R,8S,11S)-5-methyl-8-(propan-2-yl)-11-[(1E)-4-sulfanylbut-1-en-1-yl]-3-thia-7,10,14,20,21-pentaazatricyclo[14.3.1.1~2,5~]henicosa-1(20),2(21),16,18-tetraene-6,9,13-trione, GLYCEROL, Histone deacetylase 8, ... Authors: Decroos, C, Christianson, D.W. Deposit date: 2014-10-22 Release date: 2015-04-08 Last modified: 2023-09-20 Method: X-RAY DIFFRACTION (2.18 Å) Cite: Variable Active Site Loop Conformations Accommodate the Binding of Macrocyclic Largazole Analogues to HDAC8. Biochemistry, 54, 2015
创建时间：
2014-10-22
