Additional file 5: Table S4. of Progression of pathology in PINK1-deficient mouse brain from splicing via ubiquitination, ER stress, and mitophagy changes to neuroinflammation

GSEA bioinformatics assessment—ranked pathways by age. Ranked pathway dysregulations are shown separately on different datasheets for the predefined Reactome and KEGG gene sets regarding down- and upregulations, and progressive ages. Green background colors for the nominal p value and the False Discovery Rate q values indicate significance according to GSEA recommendations. Neuroinflammation pathways are highlighted in red color, MAPK signaling in purple, Parkinson’s disease in yellow, ubiquitination pathways in blue, endoplasmic reticulum stress response pathways in orange, the mTOR signaling pathway (mimicked by starvation stress during in vitro experiments) in dark gray, the vesicular pathways in light brown. (XLSX 123 kb)

本数据集为按年龄排序的基因集富集分析（Gene Set Enrichment Analysis, GSEA）生物信息学评估结果。针对预定义的Reactome数据库基因集与京都基因与基因组百科全书（Kyoto Encyclopedia of Genes and Genomes, KEGG）基因集，分别将按基因表达下调、上调调控及渐进性年龄分层得到的排序通路失调情况展示于不同工作表中。根据GSEA的推荐标准，背景色为绿色的名义p值与错误发现率q值（FDR q值）代表结果具有统计学显著性。本次分析中，神经炎症通路以红色高亮标注，丝裂原活化蛋白激酶（MAPK）信号通路以紫色高亮标注，帕金森病相关通路以黄色高亮标注，泛素化通路以蓝色高亮标注，内质网应激反应通路以橙色高亮标注，体外实验中以饥饿应激模拟的哺乳动物雷帕霉素靶蛋白（mTOR）信号通路以深灰色高亮标注，囊泡转运通路以浅棕色高亮标注。本数据集文件格式为XLSX，大小为123 KB。