Role of differentially expressed microRNA-139-5p in the regulation of phenotypic internal anal sphincter smooth muscle tone

The present study focused on establishing the role of microRNA-139-5p (miRNA-139-5p) in the phenotypic expression of basal tone in rat internal anal sphincter (IAS) vs. lack of tone in truly phasic smooth muscle of anococcygeus (ASM), via RhoA-associated kinase (RhoA/ROCK2).本研究聚焦于明确微小RNA-139-5p（microRNA-139-5p）通过RhoA相关激酶（RhoA/ROCK2）通路，在大鼠肛门内括约肌（IAS）基础张力的表型表达，以及肛管直肠肌真正时相性平滑肌（ASM）无张力状态中的作用差异。