Supporting data for "Age and vaccine-dependent anti-NA antibody response against A(H1N1) and A(H1N1)pdm09 influenza viruses".

There are 4 main datasets included
1. The NI titers measured for post-infection ferret anti-sera using Enzyme-Linked Lectin Assay (ELLA) to characterise the N1 NA antigenic drifts of A(H1N1) viruses between 1977-1991. 
2. The HI and NI titers measured in individuals aged 5-70 years using HI assay and ELLA, respectively, to observe the immune imprinting patterns across a panel of antigenically distinct HA and NA proteins of A(H1N1) and A(H1N1)pdm09 viruses from 1977-2015.
3. The NI antibody titers measured using ELLA against antigenically distinct NAs from A(H1N1) and A(H1N1)pdm09 viruses from 1977-2009 in individuals who were infected with A(H1N1)pdm09 virus during 2013-2016 to observe the back-boosting of NI antibodies.
4. The NI titers measured using ELLA in individuals who recieved a single dose of SIIV and eIIV during 2017/2018 influenza season and NI titers in individuals who were repeatedly vaccinated for 2 influenza seasons (2017/2018, 2018/2019) using homologous and heterologous vaccines. Additionally, the NI titers measured using ELLA for a historical A(H1N1) strain in individuals who received a single dose of SIIV and eIIV during 2017/2018 influenza season to observe the back-boosting of NI antibodies with vaccination.

本数据集包含四个主要数据集：
1. 利用酶联凝集素测定法（ELLA）对1977-1991年间感染后狐狸抗血清的NI滴度进行测量，以表征A(H1N1)病毒N1 NA抗原性漂移。
2. 使用HI测定法和ELLA分别测量5-70岁个体的HI和NI滴度，观察A(H1N1)和A(H1N1)pdm09病毒中具有抗原性差异的HA和NA蛋白的免疫印记模式，时间跨度为1977-2015。
3. 使用ELLA对1977-2009年间感染A(H1N1)pdm09病毒的个人进行测量，以观察NI抗体的回增强。
4. 在2017/2018流感季节接受单一剂量SIIV和eIIV的个人以及连续两个流感季节（2017/2018，2018/2019）反复接种疫苗的个人，使用同源和异源疫苗测量NI滴度。此外，对在2017/2018流感季节接受单一剂量SIIV和eIIV的个人使用ELLA测量的历史A(H1N1)菌株的NI滴度，以观察疫苗接种导致的NI抗体回增强。