Data from: Long-term test–retest reliability of striatal and extrastriatal dopamine D2/3 receptor binding: study with [11C]raclopride and high-resolution PET

We measured the long-term test–retest reliability of [11C]raclopride binding in striatal subregions, the thalamus and the cortex using the bolus-plus-infusion method and a high-resolution positron emission scanner. Seven healthy male volunteers underwent two positron emission tomography (PET) [11C]raclopride assessments, with a 5-week retest interval. D2/3 receptor availability was quantified as binding potential using the simplified reference tissue model. Absolute variability (VAR) and intraclass correlation coefficient (ICC) values indicated very good reproducibility for the striatum and were 4.5%/0.82, 3.9%/0.83, and 3.9%/0.82, for the caudate nucleus, putamen, and ventral striatum, respectively. Thalamic reliability was also very good, with VAR of 3.7% and ICC of 0.92. Test-retest data for cortical areas showed good to moderate reproducibility (6.1% to 13.1%). Our results are in line with previous test–retest studies of [11C]raclopride binding in the striatum. A novel finding is the relatively low variability of [11C]raclopride binding, providing suggestive evidence that extrastriatal D2/3 binding can be studied in vivo with [11C]raclopride PET to be verified in future studies.

本研究采用弹丸-持续输注法（bolus-plus-infusion method）与高分辨正电子发射扫描仪，评估了纹状体亚区、丘脑及皮层中[11C]雷氯必利（[11C]raclopride）受体结合的长期重测信度。七名健康男性志愿者先后完成两次[11C]雷氯必利正电子发射断层扫描（positron emission tomography, PET）评估，两次评估的重测间隔为5周。采用简化参考组织模型（simplified reference tissue model）将D2/3受体可用性量化为结合潜能（binding potential）。绝对变异性（absolute variability, VAR）与组内相关系数（intraclass correlation coefficient, ICC）结果显示，纹状体整体具有极佳的重测可重复性：尾状核、壳核与腹侧纹状体的VAR/ICC分别为4.5%/0.82、3.9%/0.83及3.9%/0.82。丘脑的重测信度同样优异，VAR为3.7%，ICC为0.92。皮层区域的重测数据则呈现良好至中等程度的可重复性，变异范围为6.1%~13.1%。本研究结果与此前针对纹状体[11C]雷氯必利结合的重测研究结论一致。本研究的一项新发现为[11C]雷氯必利结合的变异性相对较低，这为采用[11C]雷氯必利PET在活体中研究纹状体以外区域的D2/3受体结合提供了初步证据，该结论有待未来研究进一步验证。