RNA-seq of mouse spermatogonia cells at three developmental stages (PND8, PND15 and adult)

In mammals, spermatogonial cells are undifferentiated male germ cells in testes that exit quiescence after birth, and self-renew or differentiate to produce spermatogenic cells and functional sperm across life. However, what drives this developmental transition at the transcriptional and chromatin level is still poorly understood. Here we characterized the transcriptome and chromatin accessibility landscape of the genome from spermatogonial cells purified at different stages of postnatal development and in adult.