Human fetal pancreas transcriptome analysis
收藏干细胞与再生医学数据中心2022-02-20 更新2024-03-06 收录
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http://data.iscr.ac.cn/Article?id=8fc0f5691042f31afafe05b5b8169d42
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To characterize the transcriptional programs that underlie pancreas differentiation and identity, we have generated genome-scale expression profiles by RNA-seq from human embryonic stem cell derived liver progenitors and human fetal pancreatic tissue (days 54-57 post conception). These samples were compared to those already published transcriptomes (Xie et al., 2013). Together, these samples were used to perform principles compotent analysis. Once this was performed, we were able to identify transcription factors that were important in the identity of each cell type.
为解析驱动胰腺分化与细胞身份确立的转录调控程序，我们通过RNA测序（RNA-seq）技术，获取了人胚胎干细胞来源的肝脏祖细胞以及妊娠后54-57天人类胎儿胰腺组织的全基因组表达谱。将上述样本与已发表的转录组数据（Xie等，2013）进行比对分析。我们整合所有样本，开展了主成分分析（Principal Component Analysis）。完成上述分析后，我们成功鉴定出对各细胞类型身份确立具有关键作用的转录因子。
提供机构：
UC San Diego创建时间：
2022-02-20
