Genetic Associations in Aging

**Overview**
This data package contains information on genetic associations in aging and all genes related to aging, senescence and longevity both in humans and animals.

**Description**
This data package contains datasets on genetic associations in aging including all genes related to aging or longevity in humans, animals and common model organisms in aging as human homologs as well as genetic associations of gene expression signatures of aging from a meta-analysis of microarray studies in various mammals. All Genes Related to Aging from The Human Dataset include a list of all genes related to aging in humans such as GenAge ID, symbol, aliases, name, Entrez gene id, SwissProt/UniProt, band, location start, location end, orientation, enzyme acetyl-CoA carboxylase promoter, orf, CDs, references and orthologs. Common Model Organisms in Aging as Human Homologs include a list of genes with a common ancestral DNA sequence with humans. Genes Related to Human Aging from Microarray Studies in Mammals include a database of genetic associations of gene expression signatures of aging from a meta-analysis of microarray studies in mammals. Genetic Dietary Restriction (GenDR) Expressions from Studies in Mammals dataset is an informational resource on genes related to dietary restriction (DR), the most powerful non-genetic intervention shown to extend lifespan in a wide range of model organisms. The Animal Ageing (AnAge) and Longevity Database is a database of longevity, aging, and life history in extant species employing the same engine of GenAge.

**Benefits**
- This data package can be useful for further gene research and genetic studies.

**License Information**
The use of John Snow Labs datasets is free for personal and research purposes. For commercial use please subscribe to the [Data Library](https://www.johnsnowlabs.com/marketplace/) on John Snow Labs website. The subscription will allow you to use all John Snow Labs datasets and data packages for commercial purposes.

**Included Datasets**
- [All Genes Related to Aging from The Human Dataset](https://www.johnsnowlabs.com/marketplace/all-genes-related-to-aging-from-the-human-dataset)
- This dataset of All Genes Related to Aging from The Human Dataset is essentially a list of all genes related to aging in humans. It also includes the GenAge ID, symbol, aliases, name, Entrez gene id, SwissProt/UniProt, band, location start, location end, orientation, enzyme acetyl-CoA carboxylase promoter, orf, CDs, references, and orthologs.
- [Common Model Organisms in Aging as Human Homologs](https://www.johnsnowlabs.com/marketplace/common-model-organisms-in-aging-as-human-homologs)
- This dataset of Common Model Organisms in Aging as Human Homologs is essentially a list of genes with a common ancestral DNA sequence with humans. It also includes a brief description of the species, symbol and model organism among others. For a gene to be featured, its association with aging and/or longevity must be unambiguous, and hence most genes were selected based on genetic manipulations and not mere correlations.
- [Genes Associated With Longevity or Aging In Model Organisms](https://www.johnsnowlabs.com/marketplace/genes-associated-with-longevity-or-aging-in-model-organisms)
- This dataset of genes associated with longevity or aging in model organisms is essentially a list of genes with one or a few key references, a brief description of the phenotype or effects of genetic manipulations of the gene, human homologues of the gene, and a few external links. For a gene to be featured, its association with aging and/or longevity must be unambiguous, and hence most genes were selected based on genetic manipulations and not mere correlations.
- [Genes Related to Human Aging from Microarray Studies in Mammals](https://www.johnsnowlabs.com/marketplace/genes-related-to-human-aging-from-microarray-studies-in-mammals)
- This dataset is a manually curated database of genetic associations of gene expression signatures of aging from a meta-analysis of microarray studies in mammals that reflect current knowledge of the genetics of human aging and longevity. This dataset comes from the GenAge (Genetic Aging) section of the Human Ageing Genomic Resources (HAGR) which is a repository containing information about the genetics of human aging.
- [Genetic Dietary Restriction Expressions from Studies in Mammals](https://www.johnsnowlabs.com/marketplace/genetic-dietary-restriction-expressions-from-studies-in-mammals)
- Genetic Dietary Restriction (GenDR) Expressions from Studies in Mammals dataset is an informational resource on genes related to dietary restriction (DR), the most powerful non-genetic intervention shown to extend lifespan in a wide range of model organisms. Specifically, this dataset includes a manually curated list of a conserved molecular signature of DR generated genes from a meta-analysis of DR-differentially expressed genes in mammals ("Gene expression").
- [Genetic Dietary Restriction Gene Manipulations Database](https://www.johnsnowlabs.com/marketplace/genetic-dietary-restriction-gene-manipulations-database)
- Genetic Dietary Restriction (GenDR) Gene Manipulations Database is an informational resource on genes related to dietary restriction (DR), the most powerful non-genetic intervention shown to extend lifespan in a wide range of model organisms. Specifically, this dataset includes a manually curated list of DR-essential genes ("Gene manipulations").
- [Human Genes Commonly Altered During Aging](https://www.johnsnowlabs.com/marketplace/human-genes-commonly-altered-during-aging)
- This dataset is a manually curated database of the commonly altered genes and their common names during human aging. This dataset is part of the study of genetic associations of gene expression signatures of aging from a meta-analysis of microarray studies in various mammals. This dataset comes from the GenAge (Genetic Aging) section of the Human Ageing Genomic Resources (HAGR) which is a repository containing information about the genetics of aging.
- [Human Genetic Variants Associated With LongevityMap](https://www.johnsnowlabs.com/marketplace/human-genetic-variants-associated-with-longevitymap)
- This dataset is a manually curated database of genetic association studies of longevity and reflects current knowledge of the genetics related to human longevity.
- [The Animal Aging and Longevity Database](https://www.johnsnowlabs.com/marketplace/the-animal-aging-and-longevity-database)
- The Animal Ageing (AnAge) and Longevity Database is a database of longevity, aging, and life history in extant species employing the same engine of GenAge. The most important trait in this dataset is maximum longevity (also called maximum lifespan) because it is the most widely used parameter for comparing the rate of aging between species.

**Data Engineering Overview**
**We deliver high-quality data**
- Each dataset goes through 3 levels of quality review
- 2 Manual reviews are done by domain experts
- Then, an automated set of 60+ validations enforces every datum matches metadata & defined constraints
- Data is normalized into one unified type system
- All dates, unites, codes, currencies look the same
- All null values are normalized to the same value
- All dataset and field names are SQL and Hive compliant
- Data and Metadata
- Data is available in both CSV and Apache Parquet format, optimized for high read performance on distributed Hadoop, Spark & MPP clusters
- Metadata is provided in the open Frictionless Data standard, and its every field is normalized & validated
- Data Updates
- Data updates support replace-on-update: outdated foreign keys are deprecated, not deleted

**Our data is curated and enriched by domain experts**

Each dataset is manually curated by our team of doctors, pharmacists, public health & medical billing experts:
- Field names, descriptions, and normalized values are chosen by people who actually understand their meaning
- Healthcare & life science experts add categories, search keywords, descriptions and more to each dataset
- Both manual and automated data enrichment supported for clinical codes, providers, drugs, and geo-locations
- The data is always kept up to date – even when the source requires manual effort to get updates
- Support for data subscribers is provided directly by the domain experts who curated the data sets
- Every data source’s license is manually verified to allow for royalty-free commercial use and redistribution.

**Need Help?**
If you have questions about our products, contact us at [[e-mail]](mailto:[e-mail]).