Translocation of PTK2 to Focal complexes

As integrins do not have an intrinsic catalytic activity, the signals initiated by the ECM-integrin interactions are transduced into cells through the integrin bound protein-tyrosine kinases. PTK2 (protein-tyrosine kinase 2, also known as Focal adhesion kinase 1; FADK1, FAK) is one of the protein tyrosine kinases that plays a prominent role in integrin signaling. PTK2 has been implicated in controlling cell motility and transmitting a cell survival signal from ECM. <br><br>PTK2 is recruited to sites of integrin clustering by directly binding to integrin associated c-Src.<br>

由于整合素本身不具备内在的催化活性，由细胞外基质-整合素相互作用引发的信号通过整合素结合的蛋白酪氨酸激酶传递至细胞内部。PTK2（蛋白酪氨酸激酶2，亦称焦点粘附激酶1；FADK1，FAK）是参与整合素信号传导的关键蛋白酪氨酸激酶之一。PTK2在调控细胞运动和传递细胞生存信号至细胞外基质过程中发挥着举足轻重的作用。<br><br>PTK2通过直接结合整合素相关c-Src而被招募至整合素聚集位点。