Additional file 4 of GoM DE: interpreting structure in sequence count data with differential expression analysis allowing for grades of membership

Additional file 4. Interactive volcano plots for PBMC data. Interactive volcano plots for browsing the results from the GoM DE analyses of the PBMC data. Detailed l.e. LFC statistics are displayed on mouseover: lower and upper limit of HPD interval; posterior mean estimate; posterior z-score; and lfsr. The maximum-likelihood estimate of the expression rate, $$p_{j0}$$ p j 0 , in the “null” expression model (12) is also given. Note that the lower and upper HPD intervals were not updated in the adaptive shrinkage step and therefore should be ignored.

补充文件4：外周血单个核细胞（PBMC, Peripheral Blood Mononuclear Cell）数据交互式火山图。该交互式火山图用于浏览PBMC数据的GoM差异表达（DE, Differential Expression）分析结果。鼠标悬停时将展示详细统计信息，即对数折叠变化（LFC, Log Fold Change）相关统计量：最高后验密度（HPD, Highest Posterior Density）区间的上下限、后验均值估计值、后验Z分数以及局部假发现率（lfsr, Local False Sign Rate）。同时还给出了“零假设”表达模型（式12）中表达速率的最大似然估计值$p_{j0}$。请注意，在自适应收缩步骤中未更新上下HPD区间，因此该区间应予以忽略。