Brown Adipose YY1 Deficiency Activates Expression of Secreted Proteins Linked to Energy Expenditure and Prevents Diet-Induced Obesity [IWAT]

Analysis of subcutaneous adipose tissue (IWAT) from Yin Yang 1 brown fat specific knockout mice fed a high fat diet for 2 weeks. The goal was to identify a gene signature of IWAT browning in YY1 mutant mice. Control mice YY1flox/flox versus YY1flox/flox; Ucp1Cre were fed a high fat diet for 2 weeks本数据集针对饲喂高脂饮食（high fat diet）2周的阴阳1（YY1）棕色脂肪特异性敲除小鼠的皮下脂肪组织（subcutaneous adipose tissue，IWAT）展开分析。本研究的核心目的为鉴定YY1突变小鼠皮下脂肪组织褐变的基因特征（gene signature）。对照组小鼠为YY1flox/flox与YY1flox/flox; Ucp1Cre，两组均饲喂高脂饮食2周。