An assessment of PCV13 vaccine coverage using a repeated cross-sectional household survey in Malawi 2011-2014

Data deposited here is on a repeated (longitudinal) household survey to track PCV13 vaccine coverage in infants in a rural area of Lilongwe district, Malawi, 2012-2014.
The 13-valent pneumococcal conjugate vaccine (PCV13) was introduced in Malawi from November 2011 using a three dose primary series at 6, 10, and 14 weeks of age to reduce Streptococcus Pneumoniae-related diseases. To date PCV13 paediatric coverage in Malawi has not been rigorously assessed. We used household surveys to longitudinally track paediatric PCV13 coverage in rural Malawi.
We surveyed a total of 8,562 children in six surveys; 82% were in the older age group. Overall, in age-eligible children, two-dose and three-dose coverage increased from 30% to 85% and 10% to 86%, respectively, between March 2012 and June 2014. PCV13 coverage was higher in the older age group in all surveys. Although it varied by basin, PCV13 coverage was consistently delayed: median ages at first, second and third doses were 9, 15 and 21 weeks, respectively.
In our rural study area PCV13 introduction did not meet the Malawi Ministry of Health one-year three-dose 90% coverage target, but after two years reached levels likely to reduce the prevalence of both invasive and non-invasive paediatric pneumococcal diseases. Better adherence to the PCV13 schedule may reduce pneumococcal disease in younger Malawian children.
<p>To assess the burden of clinical and hypoxaemic pnemonia at village clinic, health centre and hospital levels in Malawi in the context of PCV13 pneumococcal vaccine roll-out.
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本数据集收录的是2012-2014年马拉维利隆圭区农村地区的重复（纵向）家庭调查数据，用于追踪婴幼儿13价肺炎球菌结合疫苗（PCV13）的接种覆盖率。
马拉维于2011年11月引入13价肺炎球菌结合疫苗（PCV13），采用6、10、14周龄三剂次基础免疫程序，以降低肺炎链球菌相关疾病的发生。截至目前，马拉维尚未对该疫苗的儿童接种覆盖率开展严格评估。本研究通过家庭调查对马拉维农村地区儿童PCV13接种覆盖率进行纵向追踪。
本研究共开展6轮家庭调查，累计纳入8562名儿童，其中82%属于大龄年龄组。整体来看，2012年3月至2014年6月期间，符合接种年龄的儿童中，两剂次和三剂次接种覆盖率分别从30%提升至85%、从10%提升至86%。所有调查轮次中，大龄年龄组的PCV13接种覆盖率均更高。尽管不同区域的接种覆盖率存在差异，但接种延迟现象普遍存在：首剂、第二剂及第三剂接种的中位年龄分别为9周、15周和21周。
在本研究的农村区域，PCV13的引入未达到马拉维卫生部设定的1年内三剂次接种覆盖率达90%的目标，但在接种两年后，覆盖率已达到可降低儿童侵袭性和非侵袭性肺炎链球菌疾病患病率的水平。若能更好地遵循PCV13免疫程序，可进一步降低马拉维低龄儿童的肺炎链球菌疾病负担。
本研究旨在评估马拉维在PCV13疫苗推广接种背景下，村诊所、卫生中心及医院层面的临床性与低氧血症性肺炎疾病负担。