FUNDC1 is phosphorylated by CK2
收藏reactome.org2025-01-09 收录
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FUNDC1-mediated mitophagy is inhibited by its phosphorylation at the Serine 13 positions in the LIR motif by CK2kinase under normoxia conditions. These phosphorylation events insure that FUNDC1 cannot bind LC3.
在常氧条件下，CK2激酶通过在LIR基序中的丝氨酸13位置对FUNDC1进行磷酸化，从而抑制由FUNDC1介导的线粒体自噬。这些磷酸化事件确保了FUNDC1无法与LC3结合。
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