A novel vitronectin peptide facilitates differentiation of oligodendrocytes from human embryonic stem cells (Synthetic ECM for oligodendrocyte differentiation)

Differentiation of oligodendrocytes (ODs) presents a challenge in regenerative medicine due to their role in various neurological diseases associated with dysmyelination and demyelination. Here, we designed a peptide derived from vitronectin (VN) using in silico docking simulation and examined its use as a synthetic substrate to support the differentiation of ODs derived from human embryonic stem cells. 8 samples