Oral and oropharyngeal cancer: epidemiology and survival analysis

ABSTRACT Objective To evaluate the epidemiological profile and survival rate of oral and oropharyngeal cancer patients seen at a university hospital. Methods A cross-sectional study was carried out by means of the pathological reports of patients with oral and oropharyngeal cancer, seen at a university hospital of the Southern Region, between January 2004 and December 2014. Information was collected on patients and tumors. The mortality rate was gathered from the patient death registry in the Mortality Information System. Data were analyzed using the Kaplan-Meier survival curve and the log-rank test to compare variables. Results The 5- and 10-year survival rates were 42% and 38%, respectively. The anatomical location had a significant association with survival rate (p=0.001), with the rates were better in the lips (p=0.04), and worse in the oropharynx (p=0.03). There were no statistically significant differences between survival rates according to age, sex, ethnicity, schooling level and histologic grade. Conclusion The survival rates of oral and oropharyngeal cancer were and associated with the anatomical site of the tumor.

摘要：
研究目的：评估某南部地区大学附属医院收治的口腔及口咽癌（oral and oropharyngeal cancer）患者的流行病学特征与生存率。
研究方法：本研究为横断面研究，选取2004年1月至2014年12月期间该医院收治的口腔及口咽癌患者的病理报告作为研究资料，收集患者与肿瘤相关信息，并通过死亡信息系统（Mortality Information System）中的患者死亡登记库获取死亡率数据。采用Kaplan-Meier生存曲线（Kaplan-Meier survival curve）与log-rank检验（log-rank test）对各变量进行比较分析。
研究结果：本研究纳入患者的5年及10年生存率分别为42%与38%。肿瘤解剖部位与生存率存在显著关联（p=0.001），其中唇部肿瘤患者生存率更高（p=0.04），口咽部肿瘤患者生存率更低（p=0.03）。不同年龄、性别、种族、受教育程度及组织学分级的患者之间，生存率未表现出统计学显著差异。
研究结论：口腔及口咽癌患者的生存率与肿瘤解剖部位相关。