A floating 3D printed formulation for the coadministration and sustained release of antihypertensive drugs - Underlying CT data

Underlying CT data of "A floating 3D printed formulation for the coadministration and sustained release of antihypertensive drugs" Paola Zgouro1, Orestis L. Katsamenis3,4, Thomas Moschakis5, Georgios K. Eleftheriadis6, Athanasios S. Kyriakidis6, Konstantina Chachlioutaki1,2, Paraskevi Kyriaki Monou1,2, Marianna Ntorkou7, Constantinos K. Zacharis7, Nikolaos Bouropoulos8,9, Dimitrios G. Fatouros1,2, Christina Karavasili1, Christos I. Gioumouxouzis1 1 Laboratory of Pharmaceutical Technology, Department of Pharmaceutical Sciences, Aristotle University of Thessaloniki, GR-54124, Thessaloniki, Greece 2 Center for Interdisciplinary Research and Innovation (CIRI-AUTH), 57001 Thessaloniki, Greece 3 μ-VIS X-Ray Imaging Centre, Faculty of Engineering and Physical Sciences, University of Southampton, Southampton, SO17 1BJ, UK 4 Institute for Life Sciences, University of Southampton, University Rd, Highfield, Southampton, SO17 1BJ, UK 5 Department of Food Science and Technology, School of Agriculture, Aristotle University of Thessaloniki, GR-541 24 Thessaloniki, Greece 6 Pharmacare Premium Limited, R&D Department, HHF003 Hal Far Industrial Estate, Birzebbugia BBG3000, Malta 7 Laboratory of Pharmaceutical Analysis, Department of Pharmacy, Aristotle University of Thessaloniki, GR-54124, Greece 8 Department of Materials Science, University of Patras, 26504 Rio, Patras, Greece 9 Foundation for Research and Technology Hellas, Institute of Chemical Engineering and High Temperature Chemical Processes, Patras, Greece Microfocus Computed Tomography (μCT) X-ray microfocus computed tomography (μCT) was employed for the characterization of the microstructure of the printed object, assessing the overall volume, porosity, local thickness and other printing defects. The imaging took place at the University of Southampton’s μ-VIS X-ray Imaging Centre (www.muvis.org) / 3D X-ray Histology facility using a customized μCT scanner optimized for 3D X-ray histology (www.xrayhistology.org) (Katsamenis et al., 2023) based on Nikon’s XTH225ST system (Nikon Metrology, Castle Donington, UK). The scanner was operated at 110 kVp / 90 μA (9.9 W), with the X-ray beam prefiltered using 0.04 mm of aluminum. The source-to-object and source-to-detector distances were 28.4 mm and 1136.7 mm, respectively, resulting in a magnification factor of 40x. Acquisition parameters included 2201 projections, averaging 4 frames per projection, with an exposure time of 177 ms per projection. The 2850 x 2850 dexels detector was binned 2x (virtual detector: 1425 × 1425 dexels), resulting in an isotropic voxel edge of 7.5 μm. The reconstructed data underwent visualization and analysis using Dragonfly software (Comet Technologies Canada Inc.; software available at http://www.theobjects.com/dragonfly).

本数据集对应论文《用于联合给药与缓释抗高血压药物的悬浮式3D打印配方》（"A floating 3D printed formulation for the coadministration and sustained release of antihypertensive drugs"）的底层CT数据。作者包括Paola Zgouro¹、Orestis L. Katsamenis³⁺⁴、Thomas Moschakis⁵、Georgios K. Eleftheriadis⁶、Athanasios S. Kyriakidis⁶、Konstantina Chachlioutaki¹²、Paraskevi Kyriaki Monou¹²、Marianna Ntorkou⁷、Constantinos K. Zacharis⁷、Nikolaos Bouropoulos⁸⁺⁹、Dimitrios G. Fatouros¹²、Christina Karavasili¹、Christos I. Gioumouxouzis¹。

1. 希腊塞萨洛尼基亚里士多德大学药学院制药技术实验室，邮编GR-54124
2. 希腊塞萨洛尼基亚里士多德大学跨学科研究与创新中心（CIRI-AUTH），邮编57001
3. 英国南安普敦大学工程与物理科学学院μ-VIS X射线成像中心，邮编SO17 1BJ
4. 英国南安普敦大学生命科学学院，大学路海菲尔德，南安普敦，邮编SO17 1BJ
5. 希腊塞萨洛尼基亚里士多德大学农业学院食品科学与技术系，邮编GR-54124
6. 马耳他Pharmacare Premium有限公司研发部，哈尔法工业区HHF003号，比尔泽布贾BBG3000
7. 希腊塞萨洛尼基亚里士多德大学药学院药物分析实验室，邮编GR-54124
8. 希腊帕特雷大学材料科学系，邮编26504里奥，帕特雷
9. 希腊国家研究与技术基金会化学工程与高温化工过程研究所，帕特雷

本研究采用微焦点计算机断层扫描（Microfocus Computed Tomography, μCT）对打印构件的微观结构进行表征，以评估其总体体积、孔隙率、局部厚度及其他打印缺陷。成像实验于南安普敦大学μ-VIS X射线成像中心（www.muvis.org）/3D X射线组织学平台开展，使用针对3D X射线组织学优化的定制化μCT扫描仪（Katsamenis等，2023；www.xrayhistology.org），该设备基于尼康XTH225ST系统搭建（尼康计量技术公司，英国多宁顿城堡）。

扫描仪工作参数设置为110 kVp / 90 μA（功率9.9 W），X射线束经0.04 mm厚铝片预过滤。源物距与源探测器距分别为28.4 mm与1136.7 mm，由此获得40倍的放大倍率。采集参数包含2201幅投影图像，每幅投影平均采集4帧，单幅投影曝光时间为177 ms。采用2850×2850探测器单元（dexels）并进行2倍像素合并处理（虚拟探测器分辨率为1425×1425像素），最终得到各向同性的7.5 μm体素边长。重建后的数据使用Dragonfly软件（加拿大Comet Technologies公司；软件获取地址：http://www.theobjects.com/dragonfly）进行可视化与分析。