Single Cell Dissection of Transcriptional Heterogeneity in HPV Positive and Negative Cervical Cancer

Here we performed single-cell RNA sequencing of more than 30,000 of cells from HPV16+ and HPV- cervical cancer patients. We comprehensively revealed the heterogeneity of both the malignant cell populations and immune lineages in HPV+ and HPV- CC, as well as the cellular crosstalks with potential relevance to tumor progression. Moreover, our results demonstrated that distinct interaction patterns in HPV+ and HPV- groups could mediate similar functions or pathways, and we further constructed a three-cell interaction resource. Four fresh samples were obtained from patients with cervical cancer who underwent concurrent chemoradiotherapy >>> Submitter declares that the raw data have not been submitted due to patient privacy concerns. <<<