Characteristics of p.R337H positive patients.

NB–Neuroblastoma; ACT–adrenocortical tumor; NA–material not available for analysis; IHC–immunohistochemistry; DBD–DNA-binding domain. Immunohistochemistry was scored as 0 (no cells positive), + (up to 25% of cells positive), ++ (26% to 50% of cells positive), +++ (51% to 75% of cells positive), or ++++ (>75% of cells positive).a Only the mutant allele was found in this tumor. It was not possible to distinguish between homozygosity or loss of heterozygosity with retention of the mutated allele in the tumor.Characteristics of p.R337H positive patients.