Crystal Structure of the first bromodomain of human BRD4 in complex with the inhibitor PFi-1
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Crystal Structure of the first bromodomain of human BRD4 in complex with the inhibitor PFi-1 Descriptor: 1,2-ETHANEDIOL, 2-methoxy-N-(3-methyl-2-oxo-1,2,3,4-tetrahydroquinazolin-6-yl)benzenesulfonamide, Bromodomain-containing protein 4, ... Authors: Filippakopoulos, P, Picaud, S, Felletar, I, Fedorov, O, von Delft, F, Arrowsmith, C.H, Edwards, A.M, Weigelt, J, Fish, P, Bunnage, M, Owen, D, Knapp, S, Cook, A, Structural Genomics Consortium (SGC) Deposit date: 2012-03-20 Release date: 2012-04-18 Last modified: 2023-09-13 Method: X-RAY DIFFRACTION (1.92 Å) Cite: Identification of a chemical probe for bromo and extra C-terminal bromodomain inhibition through optimization of a fragment-derived hit. J.Med.Chem., 55, 2012
创建时间：
2012-03-20
