GWAS summary statistics pertaining to the publication: " The genetic landscape of neuro-related proteins in human plasma"

Understanding the genetic basis of neuro-related proteins is essential for dissecting the molecular basis of human behavioral traits and the disease etiology of neuropsychiatric disorders. Here, the SCALLOP Consortium conducted a genome-wide association meta-analysis of over 12,500 individuals for 184 neuro-related proteins in human plasma. The analysis identified 125 cis-regulatory protein quantitative trait loci (cis-pQTL) and 164 trans-pQTL. The mapped pQTL capture on average 50\% of each protein's heritability. Mendelian randomization analyses revealed multiple proteins showing potential causal effects on human behavioral traits such as alcohol and food intake, smoking, and educational attainment, as well as neurological conditions and psychiatric disorders such as pain, neuroticism, and schizophrenia. Integrating with established drug information, the causal inference analysis validated 52 out of 66 matched combinations of protein targets and diseases or side effects with available drugs, while suggesting hundreds of re-purposing and new therapeutic targets. This consortium effort provides a large-scale proteogenomic resource for biomedical research on human behaviors and other neuro-related phenotypes.