Anatomy of the left atria in subjects with dyspnoea and Heart Failure with preserved Ejection Fraction

Anatomy of the left atria (LA) of patients with exertional dyspnoea and diastolic dysfunction on echocardiography (E/e’ &gt;8), that were classified as HFpEF (n=34) or non-cardiac dyspnoea (NCD, n=34) based on right heart catheterisation (RHC). All patients underwent rest and exercise-stress RHC and Cardiovascular Magnetic Resonance (CMR). Computational 3D anatomical LA models were generated based on short axis cine sequences. A fully automated pipeline was developed to segment CMR images at three instants in the cardiac cycle (end diastole ED, end systole ES and mid diastole midD) and build 3D statistical models of LA shape and find the 3D patterns discriminant between HFpEF and NCD.This dataset underpins the publication "Left Atrial Roof Enlargement Is a Distinct Feature of Heart Failure With Preserved Ejection Fraction" Circ Cardiovasc Imaging. 2024;17:e016424. DOI: 10.1161/CIRCIMAGING.123.016424Data shared contains 64 cases x 3 phases (ED, ES, midD) = 192 models:<b>1. AtlasMeshData.zip</b>, where each mesh is named as "CaseXXXphYY" where XXX is the case ID and YY is the frame of the CMR sequence used (ED will be the first or last frame, ES will be around 7, and midD will be around 20)1.1 Maskxxx.gipl: The mask of the left ventricular (LV) myocardium and right ventricular blood pool from the short axis magnetic resonance image1.2 Maskxxx_mesh files (.exelem and .exnode): the cubic Hermite mesh that was personalised to the anatomy of the left ventricle1.3 Image_Maskxxx_mesh.jpg: image of the overlay between the fitted mesh and the mask of the segmentation.1.4 Image_Initialization.jpg: image of the overlay between the template mesh used for personalization and the segmentation mask1.5 ImageDistances2ClosestPointMaskxxx_meshxxxxxxxxxx.jpg: image of the distances between the mesh and the segmentation contours (xxxxxxxxxx is a digit encoding for the time when the image was generated)1.6 PersonalizationReportMaskxxx.txt: file with metrics of mesh fitting accuracy and quality1.7 GeometricalMetrics.mat: file with metrics of mesh geometry<b>2</b><b>.</b><b> AtlasModesAtlasS4LoD2_s4_c8</b>: illustration of the 20 first modes of anatomical variation, together with the box-plot of the differences between diagnostic group (non-cardiac dyspnoea in blue, masked HFpEF in purple and overt HFpEF in red).<b>3. infocases.xls</b>: data of the 68 study subjects, including demographics and pulmonary capillary wedge pressure from RHC at rest and stress.