Heterogenous profiles between matched primary tumors and brain metastases reveals tumor evolution

Brain metastases (BMs) are the most common central nervous system (CNS) malignant tumors, with rapid disease progression and extremely poor prognosis. The heterogeneity between primary tumors and BMs leads to the divergent efficacy of the adjuvant therapy response to primary tumors and BMs. However, the extent of heterogeneity between primary tumors and BMs, and the evolutionary process remains little known. To deeply insight the extent of inter-tumor heterogeneity at single-patient level and the process of these evolutions, we retrospectively analyzed a cohort of matched primary tumors and BMs patients. One patient underwent four times of brain metastatic lesion surgery with diverse locations and one operation for the primary lesion. The genomic between primary tumors and BMs was evaluated by utilizing the whole-exome sequencing (WESeq).