Dataset for Sign Epistasis Analysis in Protein Binding : Version 1

Description This record contains a curated dataset for studying energetic and allosteric effects in protein binding domains and KRAS interaction systems. The dataset integrates published deep mutational scanning data with additional structural-contact features generated by the depositor using molecular-structure analysis tools. The uploaded archive is organized into three main folders: Allosteric DMSThis folder contains deep mutational scanning datasets related to the study Mapping the energetic and allosteric landscapes of protein binding domains. The included protein systems are: GB1 GRB2 PDZ3 KRAS DMSThis folder contains datasets related to the study The energetic and allosteric landscape for KRAS inhibition. The included KRAS interaction systems are: KRAS_K27 KRAS_K55 KRAS_PIK3CG KRAS_RAF1 KRAS_RALGDS KRAS_SOS1 My DataThis folder contains additional structural data generated by the depositor. These data were produced using tools including GetContacts and PyMOL. They include structure-derived information such as residue contacts, spatial relationships, and related structural features that can be used together with the DMS datasets for downstream analysis.