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Transcriptome profiling reveals anti-inflammatory activity of miR-29b in multiple myeloma associated dendritic cells

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NIAID Data Ecosystem2026-03-12 收录
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https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE104831
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Dendritic cells (DCs) are among the major components of multiple myeloma (MM)-associated bone-marrow microenvironment and are involved in MM progression, growth and chemo-resistance. We observed that after 24h co-culture with different MM cell lines, DCs downregulate miR-29b expression. To gain insight on the effects of miR-29b, we performed a transcriptome analysis of DCs after transient transfection of a negative control or miR-29b mimics and 24h co-culture with U266 cell line. total RNA was obtained from dendritic cells obtained from three different healthy donors, transfected with either negative control or miR-29b mimics and co-cultured for 24h with U266 cell line
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2021-07-25
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