Crystal structure of WRN helicase domain in complex with HRO761
收藏Protein Data Bank Japan2024-05-22 更新2026-04-19 收录
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Crystal structure of WRN helicase domain in complex with HRO761 Descriptor: Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN, ZINC ION, ~{N}-[2-chloranyl-4-(trifluoromethyl)phenyl]-2-[2-(3,6-dihydro-2~{H}-pyran-4-yl)-5-ethyl-6-[4-(6-methyl-5-oxidanyl-pyrimidin-4-yl)carbonylpiperazin-1-yl]-7-oxidanylidene-[1,2,4]triazolo[1,5-a]pyrimidin-4-yl]ethanamide Authors: Scheufler, C, Meyer, M, Moebitz, H. Deposit date: 2023-06-16 Release date: 2024-04-24 Last modified: 2024-05-22 Method: X-RAY DIFFRACTION (1.9 Å) Cite: Discovery of WRN inhibitor HRO761 with synthetic lethality in MSI cancers. Nature, 629, 2024
创建时间：
2023-06-16
