The effect of nilotinib, imatinib and dasatinib on the sensitivity of HEK293-pcDNA3.1 and HEK-MRP7-2 cells to paclitaxel, vincristine and doxorubicin.

aValues represent the mean±SD of at least three independent experiments performed in triplicate.
bFold resistance was the IC50 values for paclitaxel, vincristine, and doxorubicin of HEK293-pcDNA3.1 in the presence of either nilotinib, imatinib or dasatinib, or the transfected cells HEK-MRP7-2 with or without the reversing agents, divided by the IC50 values for paclitaxel, vincristine, and doxorubicin of HEK293-pcDNA3.1 cells without the reversing agents. Cell survival was determined by the MTT assay as described in “Section 2”.
cDose-modifying factor was the ratio of IC50 values without reversal agent to the IC50 values with reversal agents. * Significantly different from the control transfected as assayed by the Student's t-test (P<0.05); ** P<0.01. The experiments were repeated at least three times.