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RNA-seq sequencing data from individual (S)-DAC-resistant HAP-1 clones

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NIAID Data Ecosystem2026-03-13 收录
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https://www.ncbi.nlm.nih.gov/sra/SRP286835
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In order to identify the mechanism of action of cytotoxic dialkynylcarbinols (DACs), human pseudo-haploid HAP-1 cells were mutagenized with EMS and the mutagenized population was selected with a lethal 0.25 uM concentration of a (S)-DAC. Individual clones were isolated (DACR clones) and four of them, plus the wild-type HAP-1, were submitted to RNA-seq to identify mutations conferring resistance to (S)-DAC.
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2021-12-31
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